DESIGNING HIGHLY MULTIPLEX PCR PRIMER SETS WITH SIMULATED ANNEALING DESIGN USING DIMER LIKELIHOOD ESTIMATION (SADDLE)

Designing highly multiplex PCR primer sets with Simulated Annealing Design using Dimer Likelihood Estimation (SADDLE)

The design of highly multiplex PCR primers to amplify and enrich many different DNA Jacket sequences is increasing in biomedical importance as new mutations and pathogens are identified.The authors present and experimentally validate Simulated Annealing Design using Dimer Likelihood Estimation (SADDLE), a stochastic algorithm for design of highly m

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Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?

Dietary guidelines universally advise adherence to plant-based diets.Plant-based foods confer considerable health benefits, partly attributable to their abundant micronutrient (e.g., polyphenol) content.Interest in polyphenols is largely focused on the contribution of their antioxidant activity to the prevention of various disorders, including card

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Advanced Cell Therapies for Glioblastoma

The sheer ubiquity of Gioblastoma (GBM) cases would lead you to believe that there should have been many opportunities for the discovery of treatments to successfully render it into remission.Unfortunately, its persistent commonality is due in large part to the fact that it is the most treatment-resistant tumors in adults.That completely changes th

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